新浦京集团350vip
新浦京集团350vip 新浦京集团350vip


 

 


基本信息:

郭宾,男,博士,教授。

通讯地址:湖南省长沙市麓山路36号, 新浦京集团350vip 410081

E-mail:binguo@hunnu.edu.cn

 

教育工作经历:

1999年毕业于新浦京集团350vip生物化学专业,2002年获有机分析硕士学位,2005年获中国科学院上海药物研究所药理学博士学位。2005-2007年入职中国科学院广州生物医药与健康研究院,任助理研究员。2007年调入新浦京集团350vip制药工程系和化学生物学及中药分析教育部重点实验室,先后担任助理研究员、副教授,2017年晋升为教授。2017-2018年公派赴加拿大Queen's University(女王大学)访问学者。

 

个人简介:

主要从事基于色谱-质谱技术的复杂生物样品代谢谱分析、食品安全和中药代谢/毒性机制研究。在相关领域重要学术刊物以第一或通讯作者发表高质量论文30余篇(总被引用次数1000以上、h-index 20、RG score 36.59),参与出版专著3部、获国家发明专利5项。主持完成国家自然科学基金项目2项,参与完成一类新药临床前药代及毒代动力学研究1项、广州市科技攻关重大项目1项、国家自然科学基金3项、863计划课题3项。曾获新浦京集团350vip“杨树达奖”学术作品类一等奖、中科院上海分院第三届研究生学术讨论会论文二等奖、湖南省优秀硕士论文奖、湖南省科技进步二等奖、中国中西医结合学会科学技术三等奖等。现为美国生物化学与分子生物学学会ASBMB、中国药理学会、中国化学会和中国毒理学会会员;担任国际期刊Current Drug Metabolism编委、中国药理学会药物代谢专业委员会委委员、湖南省预防医学会食品安全专业委员会常务委员、植化单体开发与利用湖南省重点实验室学术委员会委员等职。为Anal Chem、 Biosens Bioelectron、J Chromatogr A等7家国际期刊审稿人,获Elsevier杰出审稿人奖(Outstanding Reviewer Award 2015、2018)。

主讲本科教学课程《药理学》、《分析化学实验》、《仪器分析》和研究生课程《高等药理学》。在全国大学化学教学研讨会发表教改论文2篇,并作“浅析大学分析化学实验教学中理论与实践的结合点”的口头报告。入选湖南省普通高校青年骨干教师(优秀)和湖南省教育人物志(1978-2015)。已培养药物分析、分析化学硕士生23名,3人获研究生国家奖学金。指导大学生团队荣获“众泰杯”长沙市第十二届大学生科技创新创业大赛三等奖、湖南省“创青春”大学生创业大赛金奖。

 

承担项目:

1. 湖南省自然科学基金面上项目,肽靶向羰-氨交联反应活性谱与致敏乳蛋白修饰机理(2021JJ30443),2021-2023,主持在研;

2. 国家留学基金委青年骨干教师公派出国研修访问学者项目(201606725024),2017-2018,主持完成;

3. 湖南省普通高校青年骨干教师培养对象项目(830136-2081), 2014-2016,主持完成;

4. 国家自然科学基金面上项目,中药注射剂茵栀黄的反应性代谢谱及致敏潜因研究(81274178),2013-2016,主持完成;

5. 国家自然科学基金青年项目,药酶依赖反应性分子组的级联标记与靶代谢谱分析(21005027),2011-2013,主持完成;

6. 化学生物学及中药分析教育部重点实验室开放基金,中药活性小分子对代谢酶催化的调节机制(KLCBTCMR2009-06),2009-2011,主持完成。

 

发表论著:

1. Wang M, Liu Y, Guo B*, Zhang F, Chou F, Ma M, Huang L, Luo Z, Chen B, Chen X*. Isotope-Coding Derivatization for Quantitative Profiling of Reactive α-Dicarbonyl Species in Processed Botanicals by Liquid Chromatography-Tandem Mass Spectrometry. J Agric Food Chem. 2021, 69(35): 10379–10393.

2. Huang X, Zhang L, Wei L, Wang M, Li B, Guo B*, Ma M. One-Pot Derivatization for Wide-Scope Detection of Nucleobases and Deoxyribosides in Natural Medicinal Foods with Liquid Chromatography-Tandem Mass Spectrometry. J Agric Food Chem. 2020, 68(37): 10200–10212.

3. Guo B, Zhang Y, Hicks G, Huang X, Li R, Roy N, Jia Z*. Structure-Dependent Modulation of Substrate Binding and Biodegradation Activity of Pirin Proteins toward Plant Flavonols. ACS Chem Biol. 2019;14(12): 2629–2640. 【封面论文】https://pubs.acs.org/doi/10.1021/acschembio.9b00575

4. Wang M, Liu Y, Guo B*, Wei L, Teng H, Chen X*, Ma M. A dilute-and-shoot multispectral integration approach towards nontargeted component profiling of traditional herbal Yin-zhi-huang using liquid chromatography-photodiode array-ion trap/time-of-flight characterization. J Chromatogr B Analyt Technol Biomed Life Sci. 2018, 1087-1088: 118–132.

5. Liu Y, Li H, Guo B*, Wei L, Chen B*, Zhang Y. Gold nanoclusters as switch-off fluorescent probe for detection of uric acid based on the inner filter effect of hydrogen peroxide-mediated enlargement of gold nanoparticles. Biosens Bioelectron. 2017, 91: 734–740.【高被引论文】https://phytochem.hunnu.edu.cn/info/1046/1088.htm

6. Cheng Y, Zhou J, Wang M, Liu Y, Guo B*, Chen B. Single-shot multi-reaction monitoring of intact marker conjugates for quantitative profiling of human major microsomal glucuronidations and its utility to screen inhibitors from medicinal herbs. Anal Bioanal Chem. 2016, 408(28): 8117–8132.

7. Tan Z, Luo M, Yang J, Cheng Y, Huang J, Lu C, Song D, Ye M, Dai M, Gonzalez FJ, Liu A*, Guo B*. Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation. J Pharm Pharmacol. 2016, 68(9): 1203–1213.

8. Y Liu, Z Wang, B Guo*, Q Cai*. Asymmetric synthesis of N-aryl sulfinamides: copper(I)-catalyzed coupling of sulfinamides with aryl iodides via kinetic resolution. Tetrahedron Letters, 2016, 57(22): 2379–2381.

9. Tan Z, Liu A*, Luo M, Yin X, Song D, Dai M, Li P, Chu Z, Zou Z, Ma M, Guo B*, Chen B. Geniposide inhibits alpha-naphthylisothiocyanate-induced intrahepatic cholestasis: the downregulation of STAT3 and NFκB signaling plays an important role. Am J Chin Med. 2016, 44(4): 721–736.

10. B. Guo*, M Wang, Y Liu, J Zhou, H Dai, Z Huang*, L Shen, Q Zhang, B Chen. Wide-scope screening of illegal adulterants in dietary and herbal supplements via rapid polarity-switching and multistage accurate mass confirmation using an LC-IT/TOF hybrid instrument. J Agric Food Chem.2015, 63(31): 6954-6967.

11. M. Ye, L. Tang, M. Luo, J. Zhou, B. Guo*, Y. Liu, B. Chen. Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations. Nanoscale Res Lett, 2014, 9, 642. http://www.nanoscalereslett.com/content/9/1/642

12. L. Zeng, M. Wang, Y. Yuan, B. Guo*, J. Zhou, Z. Tan, M. Ye, L. Ding, B. Chen. Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement. J. Chromatogr. B, 2014, 967:245-254.

13. L. Tang,  X. Wang,  B. Guo*, M. Ma, B. Chen, S. Zhan, S. Yao. Salt-triggered liquid phase separation and facile nanoprecipitation of aqueous colloidal gold dispersion in miscible biofluids for direct chromatographic measurement. RSC Adv., 2013, 3, 15875-15886.

14. M. Wei, P. Yin , Y. Shen, L. Zhang, J. Deng, S. Xue, H. Li, B. Guo, Y. Zhang*, S. Yao. A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells. Chem. Commun. 2013, 49(41): 4640-4642.

15. B Guo*, B Chen, A Liu, W Zhu, S Yao. Liquid chromatography-mass spectrometric multiple reaction monitoring-based strategies for expanding targeted profiling towards quantitative metabolomics. Curr. Drug Metab. 2012, 13(9): 1226-43.

16. C Huang, B Guo*, X. Wang , J Li, W Zhu, B Chen, S Ouyang, SYao. A generic approach for expanding homolog-targeted residue screening of sulfonamides using a fast matrix separation and class-specific fragmentation-dependent acquisition with a hybrid quadrupole-linear ion trap mass spectrometer. Anal. Chim. Acta, 2012, 737, 83-98.

17. W Zhu, Y Yuan, P Zhou, L Zeng, H Wang, L Tang, B Guo*, B Chen. The expanding role of electrospray ionization mass spectrometry in probing reactive intermediates in solution. Molecules, 2012, 17(10): 11507-37. (Invited review)  http://www.mdpi.com/1420-3049/17/10/11507

18. H Wang, Y Wu, Y Zhao, W Sun, L Ding, B Guo, B Chen. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food Addit Contam A.2012, 29(8): 1194-201.

19. H Wang, Y Wu, B Guo, W Sun, L Ding, B. Chen. Quantification of low-polar small molecules using room temperature ionic liquids matrix assisted desorption corona beam ionization. Analyst, 2012, 137(17): 3982-8.

20. G Xu, B Chen, B Guo*, D He, S Yao*. Detection of intermediates for edvhweiler-clarke reactions by liquid-phase reactive desorption electrospray ionization mass spectrometry. Analyst, 2011, 136(11): 2385-90.

21. G Liu, L Rong, B Guo, M Zhang, S Li, Q Wu, J Chen, B Chen, S Yao. Development of an improved method to extract pesticide residues in foods using acetontrile with magnesium sulfate and chloroform. J Chromatogr A, 2011, 1218(11): 1429–36.

22. B Guo*, Z Huang, M Wang, X Wang, Y Zhang, B Chen, Y Li, H Yan, S Yao. Simultaneous direct analysis of benzimidazole fungicides and relevant metabolites in agricultural products based on multifunction dispersive solid-phase extraction and liquid chromatography-mass spectrometry. J Chromatogr A, 2010, 1217(29): 4796–807.

23. M Wang, B Guo*, Z Huang, J Duan, Z Chen, B Chen, S Yao. Improved compatibility of liquid chromatography with electrospray tandem mass spectrometry for tracing occurrence of barbital homologous residues in animal tissues. J Chromatogr A, 2010, 1217(17): 2821–31.

24. H Shen, MM He, H Liu, SA Wrighton, L Wang, B Guo, C Li. Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug Metab Dispos, 2007, 35(8):1292–300.

25. B Guo, C Li*, G Wang, L Chen. Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma. Rapid Commun Mass Spectrom, 2006, 20(1): 39–47.

26. B Guo, C Li*, Z Deng, S Chen, Z Ji, J Zhang, M Chen, F Xu. A new method for measurement of (-)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs. Rapid Commun Mass Spectrom, 2005, 19(19): 2840–48.

27. B Guo, Y Yuan, Y Wu, Q Xie, S Yao*. Assay and analysis for anti- and pro-oxidative effects of ascorbic acid on DNA with bulk acoustic wave impedance technique. Anal Biochem, 2002, 305(2): 139–48.

28. 杨子辉, 程雨晴, 陈应庄, 郭宾*, 马铭, 陈波*. 功能食品安全检测的技术现状与对策. 中国科学:化学, 2016, 46 (3): 257−262.

29. 谭桢, 刘爱明, 罗敏, 郭宾*. 茵栀黄注射液抗胆汁淤积药效成分的筛选及其作用机制研究. 中国中药杂志, 2016, 41(6): 1113−1118.

30. 刘妍妍, 程雨晴, 谭桢, 郭宾*. 药物代谢细胞色素酶催化活性检测新技术进展(特邀封面论文). 化学研究, 2015, 26(6): 551−560.

31. 郭宾*, 段俊敏, 王美玲, 王晓莹, 陈波. 自动流注-串联质谱法快速筛选植物提取物对药物代谢酶的抑制潜性. 分析化学, 2010, 38(12): 1692-7.

32. 郭宾, 戴仁科*. 代谢组学及其研究策略和分析方法进展,中国卫生检验杂志, 2007, 17(3): 554-63.

33. 郭宾,李川*. 药物与血浆蛋白结合的药理学基础及其研究进展.中国临床药理学与治疗学, 2005,10(3): 241-53.

 

国际学术交流:

1) “液-质”联用技术面向复杂体系小分子药物的分析策略,岛津公司第二届合作实验室学术研讨会,2010.10.22,北京。(大会报告)http://www.instrument.com.cn/news/20101025/049590.shtml

2) 2012年,应药物代谢领域国际期刊Curr Drug Metab主编邀请担任客座编辑(guest editor),组织来自中国、德国、巴西、加拿大、葡萄牙等国家的学者出版了一期热点研究专辑“LC-MS-based analytical strategies for targeted profiling of metabolites/biomarkers in complex systems”(http://www.eurekaselect.com/103482/article),促进了药物复杂体系代谢谱研究的国际学术交流。现担任该杂志编委。链接:https://www.eurekaselect.com/node/592/current-drug-metabolism/editorial-board

3) 2015年,美国化学会新闻周刊(ACS News Service Weekly PressPac)以“从膳食补充剂中铲除伟哥和其他隐藏的成分”(Rooting out Viagra and other hidden ingredients from dietary supplements)为题报道和评述了本团队利用LC-IT/TOF技术非目标广谱筛查功能食品违禁添加物的突破性进展工作。其后,该研究成果又被ScienceDaily(美国科学日报)、PhysOrg、Newswise、News-Medical、Eurekalert、Medical News Today、Business Standard(印度商业标准日报)等多家国际科技新闻杂志或科技网站报道和转载。链接:https://www.acs.org/content/acs/en/pressroom/presspacs/2015/acs-presspac-august-5-2015/rooting-out-viagra-and-other-hidden-ingredients-from-dietary-sup.html

4) 应邀参加喀山联邦大学举办的“喀山联邦大学-新浦京集团350vip第三届交叉科学论坛”(2018.10-11,俄罗斯喀山),报告题目Xeno-metabolite Profiles: Analytical Strategies and Drug Metabolism Mechanisms,双方青年学者交换了报告并进行了科研合作讨论。https://news.hunnu.edu.cn/info/1009/35884.htm

5) 与加拿大女王大学首席结构生物学家Zongchao Jia教授合作,在槲皮素金属酶催化氧化代谢机理方面取得重要进展,相关成果发表在知名刊物ACS Chem Biol(https://phytochem.hunnu.edu.cn/info/1046/1348.htm),并入选期刊首封面 (Front Cover)论文。链接:https://pubs.acs.org/toc/acbcct/14/12  


 

 

 

 

 

 


 

 

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